Asymptotics in response-adaptive designs generated by a two-color, randomly reinforced urn
The Annals of Statistics · 2009 · Volume 37 · Issue 2
Abstract
This paper illustrates asymptotic properties for a response-adaptive design generated by a two-color, randomly reinforced urn model. The design considered is optimal in the sense that it assigns patients to the best treatment, with probability converging to one. An approach to show the joint asymptotic normality of the estimators of the mean responses to the treatments is provided in spite of the fact that allocation proportions converge to zero and one. Results on the rate of convergence of the number of patients assigned to each treatment are also obtained. Finally, we study the asymptotic behavior of a suitable test statistic.
Keywords
60F05, 60F15, 62L05, Adaptive designs, asymptotic normality, Clinical trials, estimation and inference, ethical allocation, generalized Pólya urn, mixing convergence, optimal allocation, rate of convergence, testing mean differences, treatment allocation, two-sample t-test
Enable JavaScript for citation tools and additional paper interactions.