A Multiobjective Approach for Sector Duration Optimization in Stereotactic Radiosurgery Treatment Planning
Oylum S¸eker, Mucahit Cevik, Merve Bodur, Young Lee, Mark Ruschin
INFORMS Journal on Computing · 2023 · Volume 35 · Issue 1
Abstract
Sector duration optimization (SDO) is a problem arising in treatment planning for stereotactic radiosurgery on Gamma Knife. Given a set of isocenter locations, SDO aims to select collimator size configurations and irradiation times thereof such that target tissues receive prescribed doses in a reasonable amount of treatment time and healthy tissues nearby are spared. We present a multiobjective linear programming model for SDO to generate a diverse collection of solutions so that clinicians can select the most appropriate treatment. We develop a generic two-phase solution strategy based on the ε -constraint method for solving multiobjective optimization models, 2phas ε , which aims to systematically increase the number of high-quality solutions obtained, instead of conducting a traditional uniform search. To improve solution quality further and to accelerate the procedure, we incorporate some general and problem-specific enhancements. Moreover, we propose an alternative version of 2phas ε , which makes use of machine learning tools to reduce the computational effort. In our computational study on eight previously treated real test cases, a significant portion of 2phas ε solutions outperformed clinical results and those from a single-objective model from the literature. In addition to significant benefits of the algorithmic enhancements, our experiments illustrate the usefulness of machine learning strategies to reduce the overall run times nearly by half while maintaining or besting the clinical practice. History: Accepted by Paul Brooks, Area Editor for Applications in Biology, Medicine, and Healthcare. Funding: This work was supported in part by the Natural Sciences and Engineering Research Council of Canada [Discovery Grant RGPIN-2019-05588]. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplementary Information [ https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.1252 ] or is available from the IJOC GitHub software repository ( https://github.com/INFORMSJoC ) at [ http://dx.doi.org/10.5281/zenodo.7048848 ].
Keywords
multiobjective optimization, sector duration optimization, stereotactic radiosurgery, ε-constraint method, two-phase algorithm
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